Project Title
B7H3 CAR-Ts for B7H3+ relapsed/refractory pediatric solid tumors
Layman’s summary
Children and young adults with relapsed or treatment-resistant solid tumors have had less than a 20% survival rate for decades, highlighting the need for new therapies. This project is testing a new B7H3-targeted CAR T cell treatment enhanced with dasatinib during manufacturing to improve T-cell function. Early trial results show encouraging signs of activity. The goal is to assess its safety and effectiveness, offering new hope for patients with few remaining options.
This grant was co-funded by Trial Blazers for Kids.
Sneha Ramakrishna
This Project By The Numbers
Additional CKc Funded Research
